This is the inability to release an egg every month and is a cause of infertility in 25%. Commonly women who do not ovulate have irregular or infrequent menstrual cycles. Polycystic ovary syndrome is the commonest cause of anovulation.
Other causes include thyroid dysfunction, anorexia and obesity, disorders of the pituitary and hypothalamus (structures in the brain that control hormone levels). Lastly it can be caused by ovarian failure after chemotherapy, radiotherapy or surgery to the ovaries or chronic illness.
In women with PCD, like other chronic illnesses when you are unwell you may lose weight and the cycles may become irregular due to lack of ovulation. More rarely medication or serious illness may cause irreversible damage to the ovaries.
Restoring weight to normal can allow menstrual cycle to become regular again. Medication like clomiphene or treatments like intrauterine insemination (IUI) can be given to restore ovulation. If there is ovarian failure then egg donation is the only fertility option.